| Name | Size | DLs |
|---|
| E=M6 Defi Cerebral (France) | 2.17 mb | 935 |
| EA Playground | 20.96 mb | 1846 |
| Easy Piano | 8.89 mb | 1530 |
| Eco-Creatures - Save the Forest | 5.11 mb | 1562 |
| Ecolis - Aoi Umi to Ugoku Shima (Japan) | 6.56 mb | 1781 |
| Ed, Edd n Eddy - Scam of the Century | 7.93 mb | 1946 |
| Edo Bunka Rekishi Kentei DS (Japan) | 16.51 mb | 1344 |
| Edogawa Ranpo no Kaijin Nijuu Mensou DS (Japan) | 6.84 mb | 1525 |
| Eds Farm (Europe) (En,Fr,De,Es,It) | 3.21 mb | 1189 |
| Egg Monster Hero (Japan) | 15.06 mb | 1500 |
| Eggheads (Europe) | 1.49 mb | 1053 |
| Eibun Tadoku DS - Sekai no Bungaku Senshuu (Japan) [b] | 3.20 mb | 1186 |
| Eibun Tadoku DS - Sekai no Meisaku Douwa (Japan) | 3.86 mb | 1209 |
| Eigo de Asobou - Mummy Talk DS (Japan) (NDSi Enhanced) | 112.10 mb | 2339 |
| Eigo de Tabisuru - Little Charo (Japan) | 442.00 mb | 2789 |
| Eigo o Taberu Fushigi na Ikimono - Marsh (Japan) | 33.77 mb | 1429 |
| Eigyoudou, The (Japan) | 4.26 mb | 1201 |
| Eijukugo Target 1000 DS | 37.61 mb | 1726 |
| Eiken DS (Japan) | 28.33 mb | 1463 |
| Eiken DS Training (Japan) | 29.52 mb | 1491 |
| Eiken Kakomondai Shuuroku - Eiken DS 2 Deluxe (Japan) | 182.86 mb | 3170 |
| Eiken-ou - 2-kyuu Hen (Japan) | 58.49 mb | 1622 |
| Eiken-ou - 3-kyuu Hen (Japan) | 18.50 mb | 1319 |
| Eiken-ou - 4-kyuu Hen (Japan) | 17.11 mb | 1311 |
| Eiken-ou - Jun-2-kyuu Hen (Japan) | 33.04 mb | 1672 |
| Eikoh Seminar Koushiki DS Kyouzai - Chuugaku Eitango - Eitan Zamurai DS (Japan) [b] | 69.50 mb | 2952 |
| Eikoh Seminar Koushiki DS Kyouzai - Koukou Eitango - Eitan Zamurai DS (Japan) | 87.08 mb | 3216 |
| Eikoh Seminar Koushiki DS Kyouzai - Shougakkou Eigo - Eitan Zamurai DS (Japan) | 71.99 mb | 1605 |
| Eitango Target 1900 DS (Japan) | 26.77 mb | 1400 |
| Elebits - Kaiwa Zeroui Sinbihan Yeohaeng (Korea) [b] | 23.67 mb | 1177 |
| Elebits - The Adventures of Kai and Zero | 33.45 mb | 2293 |
| Electroplankton | 7.07 mb | 2146 |
| Element Girls - Style Your Life! (Europe) (Fr,De) | 9.77 mb | 1452 |
| Element Girls (Germany) [b] | 4.85 mb | 965 |
| Element Hunters | 11.21 mb | 1876 |
| Element Hunters (Korea) [b] | 11.20 mb | 1226 |
| Elemental Monster - Itsu Hashira Gami no Nazo (Japan) | 67.74 mb | 1749 |
| Elements of Destruction | 2.54 mb | 1262 |
| Elf Bowling 1 & 2 (USA) | 898.70 kb | 1110 |
| Elite Beat Agents | 445.86 mb | 6892 |
| Elite Forces - Unit 77 | 8.93 mb | 1715 |
| Elminage - Yami no Miko to Kamigami no Yubiwa - DS Remix (Japan) | 65.62 mb | 2130 |
| Elminage II - Sousei no Megami to Unmei no Daichi - DS Remix (Japan) (NDSi Enhanced) [b] | 68.53 mb | 2059 |
| Elvenland | 2.38 mb | 1226 |
| Emblem of Gundam (Japan) | 34.62 mb | 2008 |
| Emergency 2012 (Germany) | 13.23 mb | 1154 |
| Emergency DS (Germany) [b] | 14.34 mb | 1065 |
| Emergency Kids (Germany) | 12.30 mb | 1095 |
| Emergency Room - Real Life Rescues (USA) | 9.30 mb | 1595 |
| Emergency! - Disaster Rescue Squad | 14.78 mb | 1628 |
| Emily - My Dog Paradise (Europe) (En,Fr,It) [b] | 8.02 mb | 1342 |
| Emily - My Personal Diary (Europe) (En,Fr,De,Es,It,Nl) [b] | 3.06 mb | 1067 |
| Emily Archer - The Curse of King Tuts Tomb | 14.12 mb | 1613 |
| Emily the Strange - Strangerous | 39.49 mb | 1958 |
| Emma at the Farm | 12.31 mb | 1976 |
| Emma in the Mountains | 7.20 mb | 1474 |
| Enchanted | 13.00 mb | 1661 |
| Ener-G - Dance Squad | 57.00 mb | 2280 |
| Ener-G - Gym Rockets | 7.02 mb | 1309 |
| Ener-G - Horse Riders | 22.85 mb | 1412 |
| Englisch Buddy | 58.33 mb | 1566 |
| Englisch Entdecken Mit Ben & Bella (Germany) (En) | 13.35 mb | 1091 |
| Englisch Macht Spass - Eine Reise nach London! (Germany) [b] | 18.97 mb | 1107 |
| English Buddy (Europe) (En,Fr,De,Es,It,Nl) [b] | 58.82 mb | 1990 |
| English Training - Have Fun Improving Your Skills | 328.87 mb | 2505 |
| Enigmistica, L (Italy) | 3.56 mb | 961 |
| Enpitsu de Oku no Hosomichi DS (Japan) | 34.68 mb | 1373 |
| Entraineur Cerebral, L - Logique (France) [b] | 8.01 mb | 1056 |
| Entraineur Cerebral, L - Perception (France) [b] | 10.37 mb | 1085 |
| EQ Trainer DS - Dekiru Otona no Communication Jutsu (Japan) | 1.15 mb | 965 |
| Equestrian Training | 10.69 mb | 1465 |
| Equestrian Training (Europe) [b] | 10.41 mb | 1106 |
| Equitation - Galops 1 a 7 (France) [b] | 11.30 mb | 1203 |
| Eragon | 37.82 mb | 2242 |
| Escape the Museum | 19.55 mb | 2323 |
| ESSE Shikkari Kakeibo DS (Japan) (Rev 1) | 4.90 mb | 1207 |
| Essential Sudoku DS | 904.21 kb | 991 |
| Etrian Odyssey | 9.85 mb | 4324 |
| Etrian Odyssey II - Heroes of Lagaard | 13.24 mb | 3960 |
| Etrian Odyssey III - The Drowned City | 21.37 mb | 4316 |
| Everythings Rosie (Europe) | 5.46 mb | 1203 |
| Exit DS | 8.63 mb | 2353 |
| Eyeshield 21 - Max Devil Power! (Japan) | 17.53 mb | 1485 |
| EZ-Flash V (World) (Unl) | 97.66 kb | 711 |
| EZ-Flash Vi (World) (Unl) | 1.69 mb | 935 |
