| Name | Size | DLs |
|---|
| Sagaia (Europe) | 120.41 kb | 1330 |
| Sangokushi 3 (Korea) (Unl) | 524.32 kb | 688 |
| Sapo Xule - O Mestre do Kung Fu (Brazil) | 72.51 kb | 652 |
| Sapo Xule - S.O.S Lagoa Poluida (Brazil) | 40.63 kb | 624 |
| Sapo Xule vs. Os Invasores do Brejo (Brazil) | 89.88 kb | 641 |
| Satellite 7 (Japan) | 21.24 kb | 1077 |
| Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) | 139.60 kb | 787 |
| Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) (Beta) | 139.64 kb | 459 |
| Scramble Spirits (Europe) | 105.84 kb | 1039 |
| SDI (Japan) | 79.86 kb | 1041 |
| Secret Command (Europe) | 66.22 kb | 950 |
| Sega Chess (Europe) | 96.93 kb | 863 |
| Sega Graphic Board (USA) (v2.0) (Proto) | 10.21 kb | 571 |
| Sega World Tournament Golf (Europe) | 93.11 kb | 775 |
| Seishun Scandal (Japan) | 21.41 kb | 1038 |
| Sensible Soccer (Europe) | 67.09 kb | 889 |
| Shadow Dancer (Europe) | 200.37 kb | 1363 |
| Shadow of the Beast (Europe) | 122.61 kb | 1085 |
| Shanghai (USA, Europe) | 65.44 kb | 1026 |
| Shanghai (USA, Europe) (Beta) | 65.36 kb | 475 |
| Shinobi (Japan) | 121.31 kb | 1253 |
| Shinobi (USA, Europe) | 121.39 kb | 2643 |
| Shooting Gallery (USA, Europe) | 40.35 kb | 907 |
| Simpsons, The - Bart vs. the Space Mutants (Europe) | 130.54 kb | 1167 |
| Simpsons, The - Bart vs. the World (Europe) | 152.68 kb | 1181 |
| Sitio do Picapau Amarelo (Brazil) | 265.11 kb | 669 |
| Sky Jaguar (Korea) | 23.70 kb | 592 |
| Slap Shot (Europe) | 91.24 kb | 670 |
| Slap Shot (Europe) (Rev 1) | 91.30 kb | 522 |
| Slap Shot (Unknown) (Beta) | 90.93 kb | 441 |
| Slap Shot (USA) | 91.14 kb | 826 |
| Smurfs, The (Europe) (En,Fr,De,Es) | 118.05 kb | 1124 |
| Solomon no Kagi - Oujo Rihita no Namida (Japan) | 55.48 kb | 1229 |
| Sonic Blast (Brazil) | 374.31 kb | 1611 |
| Sonic Chaos (Europe) | 183.56 kb | 2913 |
| Sonic The Hedgehog (USA, Europe) | 131.95 kb | 6264 |
| Sonic The Hedgehog 2 (Europe) | 187.74 kb | 4342 |
| Sonic The Hedgehog 2 (Europe) (Rev 1) | 187.66 kb | 1471 |
| Sonic The Hedgehog Spinball (Europe) | 198.15 kb | 2251 |
| Sonics Edusoft (Unknown) (Proto) | 108.62 kb | 997 |
| Space Gun (Europe) | 305.96 kb | 1129 |
| Space Harrier (Europe) | 149.45 kb | 1180 |
| Space Harrier (Japan, USA) | 149.53 kb | 2114 |
| Space Harrier 3-D (USA, Europe) | 137.84 kb | 1461 |
| Space Harrier 3D (Japan) | 137.85 kb | 1247 |
| Special Criminal Investigation (Europe) | 104.54 kb | 1093 |
| Special Criminal Investigation (Europe) (Beta) | 104.59 kb | 628 |
| Speedball (Europe) (Image Works) | 55.73 kb | 678 |
| Speedball (Europe) (Virgin) | 56.66 kb | 734 |
| Speedball 2 (Europe) | 132.22 kb | 894 |
| SpellCaster (USA, Europe) | 273.74 kb | 1459 |
| Spider-Man - Return of the Sinister Six (Europe) | 134.11 kb | 1307 |
| Spider-Man vs. The Kingpin (USA, Europe) | 135.50 kb | 1389 |
| Sports Pad Football (USA) | 47.95 kb | 723 |
| Sports Pad Soccer (Japan) | 51.94 kb | 779 |
| Spy vs Spy (Japan) | 21.27 kb | 901 |
| Spy vs Spy (Taiwan) | 21.18 kb | 478 |
| Spy vs. Spy (USA, Europe) | 21.04 kb | 1154 |
| Star Wars (Europe) | 250.61 kb | 1409 |
| Street Fighter II (Brazil) | 354.15 kb | 1531 |
| Street Master (Korea) (Unl) | 27.79 kb | 643 |
| Streets of Rage (Europe) | 179.18 kb | 1973 |
| Streets of Rage II (Europe) | 227.84 kb | 1804 |
| Strider (Unknown) (Demo) | 29.39 kb | 502 |
| Strider (USA, Europe) | 119.54 kb | 1546 |
| Strider II (Europe) | 105.69 kb | 1307 |
| Submarine Attack (Europe) | 120.41 kb | 1006 |
| Suho Cheonsa (Korea) (Unl) | 107.38 kb | 585 |
| Sukeban Deka II - Shoujo Tekkamen Densetsu (Japan) | 72.33 kb | 1105 |
| Summer Games (Europe) | 62.10 kb | 866 |
| Summer Games (Europe) (Beta) | 62.31 kb | 448 |
| Super Basketball (USA) (Sample) | 20.76 kb | 596 |
| Super Boy 4 (Korea) (Unl) | 64.14 kb | 770 |
| Super Boy II (Korea) (Pirate) | 14.09 kb | 706 |
| Super Bubble Bobble (Korea) (Unl) | 14.86 kb | 730 |
| Super Golf (Europe) (Beta) | 88.86 kb | 604 |
| Super Kick Off (Europe) (En,Fr,De,Es,It,Nl,Pt,Sv) | 88.34 kb | 806 |
| Super Monaco GP (Europe) | 88.28 kb | 715 |
| Super Monaco GP (USA) | 88.29 kb | 1271 |
| Super Monaco GP (USA) (Beta 1) | 88.31 kb | 477 |
| Super Monaco GP (USA) (Beta 2) | 88.25 kb | 496 |
| Super Off Road (Europe) | 56.16 kb | 950 |
| Super Racing (Japan) | 91.20 kb | 1054 |
| Super Smash T.V. (Europe) | 88.19 kb | 985 |
| Super Space Invaders (Europe) | 120.04 kb | 1127 |
| Super Tennis (USA, Europe) | 20.50 kb | 982 |
| Super Tetris (Korea) (Pirate) | 20.05 kb | 634 |
| Super Wonder Boy - Monster World (Japan) | 117.02 kb | 1305 |
| Super Wonder Boy (Japan, Europe) | 70.31 kb | 1483 |
| Superman - The Man of Steel (Europe) | 78.03 kb | 1212 |
