| Name | Size | DLs |
|---|
| Sagaia (Europe) | 120.41 kb | 1505 |
| Sangokushi 3 (Korea) (Unl) | 524.32 kb | 786 |
| Sapo Xule - O Mestre do Kung Fu (Brazil) | 72.51 kb | 755 |
| Sapo Xule - S.O.S Lagoa Poluida (Brazil) | 40.63 kb | 727 |
| Sapo Xule vs. Os Invasores do Brejo (Brazil) | 89.88 kb | 756 |
| Satellite 7 (Japan) | 21.24 kb | 1216 |
| Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) | 139.60 kb | 920 |
| Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) (Beta) | 139.64 kb | 526 |
| Scramble Spirits (Europe) | 105.84 kb | 1193 |
| SDI (Japan) | 79.86 kb | 1192 |
| Secret Command (Europe) | 66.22 kb | 1096 |
| Sega Chess (Europe) | 96.93 kb | 998 |
| Sega Graphic Board (USA) (v2.0) (Proto) | 10.21 kb | 672 |
| Sega World Tournament Golf (Europe) | 93.11 kb | 897 |
| Seishun Scandal (Japan) | 21.41 kb | 1191 |
| Sensible Soccer (Europe) | 67.09 kb | 1029 |
| Shadow Dancer (Europe) | 200.37 kb | 1556 |
| Shadow of the Beast (Europe) | 122.61 kb | 1241 |
| Shanghai (USA, Europe) | 65.44 kb | 1190 |
| Shanghai (USA, Europe) (Beta) | 65.36 kb | 557 |
| Shinobi (Japan) | 121.31 kb | 1416 |
| Shinobi (USA, Europe) | 121.39 kb | 2962 |
| Shooting Gallery (USA, Europe) | 40.35 kb | 1045 |
| Simpsons, The - Bart vs. the Space Mutants (Europe) | 130.54 kb | 1338 |
| Simpsons, The - Bart vs. the World (Europe) | 152.68 kb | 1369 |
| Sitio do Picapau Amarelo (Brazil) | 265.11 kb | 771 |
| Sky Jaguar (Korea) | 23.70 kb | 688 |
| Slap Shot (Europe) | 91.24 kb | 760 |
| Slap Shot (Europe) (Rev 1) | 91.30 kb | 607 |
| Slap Shot (Unknown) (Beta) | 90.93 kb | 516 |
| Slap Shot (USA) | 91.14 kb | 945 |
| Smurfs, The (Europe) (En,Fr,De,Es) | 118.05 kb | 1287 |
| Solomon no Kagi - Oujo Rihita no Namida (Japan) | 55.48 kb | 1392 |
| Sonic Blast (Brazil) | 374.31 kb | 1841 |
| Sonic Chaos (Europe) | 183.56 kb | 3404 |
| Sonic The Hedgehog (USA, Europe) | 131.95 kb | 7089 |
| Sonic The Hedgehog 2 (Europe) | 187.74 kb | 4867 |
| Sonic The Hedgehog 2 (Europe) (Rev 1) | 187.66 kb | 1698 |
| Sonic The Hedgehog Spinball (Europe) | 198.15 kb | 2534 |
| Sonics Edusoft (Unknown) (Proto) | 108.62 kb | 1106 |
| Space Gun (Europe) | 305.96 kb | 1273 |
| Space Harrier (Europe) | 149.45 kb | 1311 |
| Space Harrier (Japan, USA) | 149.53 kb | 2373 |
| Space Harrier 3-D (USA, Europe) | 137.84 kb | 1651 |
| Space Harrier 3D (Japan) | 137.85 kb | 1413 |
| Special Criminal Investigation (Europe) | 104.54 kb | 1256 |
| Special Criminal Investigation (Europe) (Beta) | 104.59 kb | 696 |
| Speedball (Europe) (Image Works) | 55.73 kb | 781 |
| Speedball (Europe) (Virgin) | 56.66 kb | 853 |
| Speedball 2 (Europe) | 132.22 kb | 1030 |
| SpellCaster (USA, Europe) | 273.74 kb | 1655 |
| Spider-Man - Return of the Sinister Six (Europe) | 134.11 kb | 1502 |
| Spider-Man vs. The Kingpin (USA, Europe) | 135.50 kb | 1591 |
| Sports Pad Football (USA) | 47.95 kb | 834 |
| Sports Pad Soccer (Japan) | 51.94 kb | 885 |
| Spy vs Spy (Japan) | 21.27 kb | 1031 |
| Spy vs Spy (Taiwan) | 21.18 kb | 551 |
| Spy vs. Spy (USA, Europe) | 21.04 kb | 1337 |
| Star Wars (Europe) | 250.61 kb | 1611 |
| Street Fighter II (Brazil) | 354.15 kb | 1734 |
| Street Master (Korea) (Unl) | 27.79 kb | 732 |
| Streets of Rage (Europe) | 179.18 kb | 2241 |
| Streets of Rage II (Europe) | 227.84 kb | 2056 |
| Strider (Unknown) (Demo) | 29.39 kb | 584 |
| Strider (USA, Europe) | 119.54 kb | 1782 |
| Strider II (Europe) | 105.69 kb | 1506 |
| Submarine Attack (Europe) | 120.41 kb | 1158 |
| Suho Cheonsa (Korea) (Unl) | 107.38 kb | 664 |
| Sukeban Deka II - Shoujo Tekkamen Densetsu (Japan) | 72.33 kb | 1257 |
| Summer Games (Europe) | 62.10 kb | 996 |
| Summer Games (Europe) (Beta) | 62.31 kb | 521 |
| Super Basketball (USA) (Sample) | 20.76 kb | 700 |
| Super Boy 4 (Korea) (Unl) | 64.14 kb | 868 |
| Super Boy II (Korea) (Pirate) | 14.09 kb | 796 |
| Super Bubble Bobble (Korea) (Unl) | 14.86 kb | 819 |
| Super Golf (Europe) (Beta) | 88.86 kb | 694 |
| Super Kick Off (Europe) (En,Fr,De,Es,It,Nl,Pt,Sv) | 88.34 kb | 930 |
| Super Monaco GP (Europe) | 88.28 kb | 812 |
| Super Monaco GP (USA) | 88.29 kb | 1430 |
| Super Monaco GP (USA) (Beta 1) | 88.31 kb | 548 |
| Super Monaco GP (USA) (Beta 2) | 88.25 kb | 574 |
| Super Off Road (Europe) | 56.16 kb | 1091 |
| Super Racing (Japan) | 91.20 kb | 1202 |
| Super Smash T.V. (Europe) | 88.19 kb | 1128 |
| Super Space Invaders (Europe) | 120.04 kb | 1294 |
| Super Tennis (USA, Europe) | 20.50 kb | 1126 |
| Super Tetris (Korea) (Pirate) | 20.05 kb | 725 |
| Super Wonder Boy - Monster World (Japan) | 117.02 kb | 1472 |
| Super Wonder Boy (Japan, Europe) | 70.31 kb | 1677 |
| Superman - The Man of Steel (Europe) | 78.03 kb | 1390 |
