| Name | Size | DLs |
|---|
| Sagaia (Europe) | 120.41 kb | 1496 |
| Sangokushi 3 (Korea) (Unl) | 524.32 kb | 783 |
| Sapo Xule - O Mestre do Kung Fu (Brazil) | 72.51 kb | 748 |
| Sapo Xule - S.O.S Lagoa Poluida (Brazil) | 40.63 kb | 715 |
| Sapo Xule vs. Os Invasores do Brejo (Brazil) | 89.88 kb | 744 |
| Satellite 7 (Japan) | 21.24 kb | 1213 |
| Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) | 139.60 kb | 912 |
| Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) (Beta) | 139.64 kb | 523 |
| Scramble Spirits (Europe) | 105.84 kb | 1186 |
| SDI (Japan) | 79.86 kb | 1189 |
| Secret Command (Europe) | 66.22 kb | 1090 |
| Sega Chess (Europe) | 96.93 kb | 992 |
| Sega Graphic Board (USA) (v2.0) (Proto) | 10.21 kb | 658 |
| Sega World Tournament Golf (Europe) | 93.11 kb | 891 |
| Seishun Scandal (Japan) | 21.41 kb | 1187 |
| Sensible Soccer (Europe) | 67.09 kb | 1022 |
| Shadow Dancer (Europe) | 200.37 kb | 1548 |
| Shadow of the Beast (Europe) | 122.61 kb | 1234 |
| Shanghai (USA, Europe) | 65.44 kb | 1183 |
| Shanghai (USA, Europe) (Beta) | 65.36 kb | 546 |
| Shinobi (Japan) | 121.31 kb | 1409 |
| Shinobi (USA, Europe) | 121.39 kb | 2944 |
| Shooting Gallery (USA, Europe) | 40.35 kb | 1040 |
| Simpsons, The - Bart vs. the Space Mutants (Europe) | 130.54 kb | 1329 |
| Simpsons, The - Bart vs. the World (Europe) | 152.68 kb | 1356 |
| Sitio do Picapau Amarelo (Brazil) | 265.11 kb | 766 |
| Sky Jaguar (Korea) | 23.70 kb | 683 |
| Slap Shot (Europe) | 91.24 kb | 759 |
| Slap Shot (Europe) (Rev 1) | 91.30 kb | 604 |
| Slap Shot (Unknown) (Beta) | 90.93 kb | 514 |
| Slap Shot (USA) | 91.14 kb | 941 |
| Smurfs, The (Europe) (En,Fr,De,Es) | 118.05 kb | 1280 |
| Solomon no Kagi - Oujo Rihita no Namida (Japan) | 55.48 kb | 1383 |
| Sonic Blast (Brazil) | 374.31 kb | 1834 |
| Sonic Chaos (Europe) | 183.56 kb | 3380 |
| Sonic The Hedgehog (USA, Europe) | 131.95 kb | 7058 |
| Sonic The Hedgehog 2 (Europe) | 187.74 kb | 4844 |
| Sonic The Hedgehog 2 (Europe) (Rev 1) | 187.66 kb | 1691 |
| Sonic The Hedgehog Spinball (Europe) | 198.15 kb | 2523 |
| Sonics Edusoft (Unknown) (Proto) | 108.62 kb | 1101 |
| Space Gun (Europe) | 305.96 kb | 1264 |
| Space Harrier (Europe) | 149.45 kb | 1303 |
| Space Harrier (Japan, USA) | 149.53 kb | 2364 |
| Space Harrier 3-D (USA, Europe) | 137.84 kb | 1639 |
| Space Harrier 3D (Japan) | 137.85 kb | 1411 |
| Special Criminal Investigation (Europe) | 104.54 kb | 1248 |
| Special Criminal Investigation (Europe) (Beta) | 104.59 kb | 695 |
| Speedball (Europe) (Image Works) | 55.73 kb | 777 |
| Speedball (Europe) (Virgin) | 56.66 kb | 845 |
| Speedball 2 (Europe) | 132.22 kb | 1024 |
| SpellCaster (USA, Europe) | 273.74 kb | 1644 |
| Spider-Man - Return of the Sinister Six (Europe) | 134.11 kb | 1493 |
| Spider-Man vs. The Kingpin (USA, Europe) | 135.50 kb | 1580 |
| Sports Pad Football (USA) | 47.95 kb | 827 |
| Sports Pad Soccer (Japan) | 51.94 kb | 882 |
| Spy vs Spy (Japan) | 21.27 kb | 1025 |
| Spy vs Spy (Taiwan) | 21.18 kb | 551 |
| Spy vs. Spy (USA, Europe) | 21.04 kb | 1325 |
| Star Wars (Europe) | 250.61 kb | 1603 |
| Street Fighter II (Brazil) | 354.15 kb | 1728 |
| Street Master (Korea) (Unl) | 27.79 kb | 727 |
| Streets of Rage (Europe) | 179.18 kb | 2226 |
| Streets of Rage II (Europe) | 227.84 kb | 2041 |
| Strider (Unknown) (Demo) | 29.39 kb | 580 |
| Strider (USA, Europe) | 119.54 kb | 1764 |
| Strider II (Europe) | 105.69 kb | 1488 |
| Submarine Attack (Europe) | 120.41 kb | 1150 |
| Suho Cheonsa (Korea) (Unl) | 107.38 kb | 660 |
| Sukeban Deka II - Shoujo Tekkamen Densetsu (Japan) | 72.33 kb | 1251 |
| Summer Games (Europe) | 62.10 kb | 990 |
| Summer Games (Europe) (Beta) | 62.31 kb | 518 |
| Super Basketball (USA) (Sample) | 20.76 kb | 686 |
| Super Boy 4 (Korea) (Unl) | 64.14 kb | 862 |
| Super Boy II (Korea) (Pirate) | 14.09 kb | 788 |
| Super Bubble Bobble (Korea) (Unl) | 14.86 kb | 813 |
| Super Golf (Europe) (Beta) | 88.86 kb | 692 |
| Super Kick Off (Europe) (En,Fr,De,Es,It,Nl,Pt,Sv) | 88.34 kb | 925 |
| Super Monaco GP (Europe) | 88.28 kb | 808 |
| Super Monaco GP (USA) | 88.29 kb | 1418 |
| Super Monaco GP (USA) (Beta 1) | 88.31 kb | 544 |
| Super Monaco GP (USA) (Beta 2) | 88.25 kb | 571 |
| Super Off Road (Europe) | 56.16 kb | 1081 |
| Super Racing (Japan) | 91.20 kb | 1192 |
| Super Smash T.V. (Europe) | 88.19 kb | 1120 |
| Super Space Invaders (Europe) | 120.04 kb | 1285 |
| Super Tennis (USA, Europe) | 20.50 kb | 1117 |
| Super Tetris (Korea) (Pirate) | 20.05 kb | 721 |
| Super Wonder Boy - Monster World (Japan) | 117.02 kb | 1463 |
| Super Wonder Boy (Japan, Europe) | 70.31 kb | 1668 |
| Superman - The Man of Steel (Europe) | 78.03 kb | 1381 |
