| Name | Size | DLs |
|---|
| Sagaia (Europe) | 135.51 kb | 715 |
| Sangokushi 3 (Korea) (Unl) | 607.74 kb | 368 |
| Sapo Xule - O Mestre do Kung Fu (Brazil) | 79.92 kb | 291 |
| Sapo Xule - S.O.S Lagoa Poluida (Brazil) | 45.57 kb | 277 |
| Sapo Xule vs. Os Invasores do Brejo (Brazil) | 102.39 kb | 450 |
| Satellite 7 (Japan) | 22.86 kb | 551 |
| Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) | 148.17 kb | 427 |
| Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) (Beta) | 148.18 kb | 183 |
| Scramble Spirits (Europe) | 124.55 kb | 501 |
| SDI (Japan) | 87.88 kb | 553 |
| Secret Command (Europe) | 73.89 kb | 557 |
| Sega Chess (Europe) | 115.77 kb | 403 |
| Sega World Tournament Golf (Europe) | 105.37 kb | 363 |
| Seishun Scandal (Japan) | 22.99 kb | 570 |
| Sensible Soccer (Europe) | 74.03 kb | 557 |
| Shadow Dancer (Europe) | 220.75 kb | 711 |
| Shadow of the Beast (Europe) | 139.64 kb | 810 |
| Shanghai (USA, Europe) | 72.09 kb | 479 |
| Shanghai (USA, Europe) (Beta) | 72.02 kb | 164 |
| Shinobi (Japan) | 133.74 kb | 646 |
| Shinobi (USA, Europe) | 133.76 kb | 1486 |
| Shooting Gallery (USA, Europe) | 46.36 kb | 401 |
| Simpsons, The - Bart vs. the Space Mutants (Europe) | 145.37 kb | 613 |
| Simpsons, The - Bart vs. the World (Europe) | 168.09 kb | 590 |
| Sitio do Picapau Amarelo (Brazil) | 318.49 kb | 434 |
| Sky Jaguar (Korea) | 25.10 kb | 442 |
| Slap Shot (Europe) | 106.27 kb | 272 |
| Slap Shot (Europe) (Rev 1) | 106.30 kb | 193 |
| Slap Shot (Unknown) (Beta) | 105.85 kb | 417 |
| Slap Shot (USA) | 106.29 kb | 403 |
| Smurfs, The (Europe) (En,Fr,De,Es) | 134.96 kb | 546 |
| Solomon no Kagi - Oujo Rihita no Namida (Japan) | 63.19 kb | 671 |
| Sonic Blast (Brazil) | 458.37 kb | 771 |
| Sonic Chaos (Europe) | 209.55 kb | 1609 |
| Sonic The Hedgehog (USA, Europe) | 146.87 kb | 3962 |
| Sonic The Hedgehog 2 (Europe) | 218.53 kb | 2280 |
| Sonic The Hedgehog 2 (Europe) (Rev 1) | 218.48 kb | 782 |
| Sonic The Hedgehog Spinball (Europe) | 234.63 kb | 922 |
| Sonic's Edusoft (Unknown) (Proto) | 123.42 kb | 538 |
| Space Gun (Europe) | 343.88 kb | 491 |
| Space Harrier (Europe) | 167.35 kb | 482 |
| Space Harrier (Japan, USA) | 167.36 kb | 1081 |
| Space Harrier 3-D (USA, Europe) | 152.88 kb | 570 |
| Space Harrier 3D (Japan) | 152.92 kb | 513 |
| Special Criminal Investigation (Europe) | 117.95 kb | 477 |
| Special Criminal Investigation (Europe) (Beta) | 117.97 kb | 136 |
| Speedball (Europe) (Image Works) | 63.43 kb | 284 |
| Speedball (Europe) (Virgin) | 64.43 kb | 354 |
| Speedball 2 (Europe) | 147.60 kb | 473 |
| SpellCaster (USA, Europe) | 299.65 kb | 737 |
| Spider-Man - Return of the Sinister Six (Europe) | 152.84 kb | 700 |
| Spider-Man vs. The Kingpin (USA, Europe) | 144.99 kb | 749 |
| Sports Pad Football (USA) | 53.20 kb | 371 |
| Sports Pad Soccer (Japan) | 59.22 kb | 355 |
| Spy vs Spy (Japan) | 22.92 kb | 397 |
| Spy vs Spy (Taiwan) | 22.81 kb | 208 |
| Spy vs. Spy (USA, Europe) | 22.68 kb | 562 |
| Star Wars (Europe) | 288.33 kb | 752 |
| Street Fighter II (Brazil) | 394.53 kb | 881 |
| Street Master (Korea) (Unl) | 38.72 kb | 409 |
| Streets of Rage (Europe) | 210.15 kb | 1174 |
| Streets of Rage II (Europe) | 257.73 kb | 999 |
| Strider (Unknown) (Demo) | 32.07 kb | 172 |
| Strider (USA, Europe) | 139.45 kb | 873 |
| Strider II (Europe) | 118.85 kb | 688 |
| Submarine Attack (Europe) | 131.35 kb | 517 |
| Suho Cheonsa (Korea) (Unl) | 123.33 kb | 389 |
| Sukeban Deka II - Shoujo Tekkamen Densetsu (Japan) | 78.58 kb | 599 |
| Summer Games (Europe) | 70.02 kb | 443 |
| Summer Games (Europe) (Beta) | 68.83 kb | 151 |
| Super Basketball (USA) (Sample) | 22.49 kb | 227 |
| Super Boy 4 (Korea) (Unl) | 81.03 kb | 879 |
| Super Boy II (Korea) (Pirate) | 23.38 kb | 957 |
| Super Bubble Bobble (Korea) (Unl) | 16.35 kb | 397 |
| Super Golf (Europe) (Beta) | 100.92 kb | 255 |
| Super Kick Off (Europe) (En,Fr,De,Es,It,Nl,Pt,Sv) | 104.73 kb | 413 |
| Super Monaco GP (Europe) | 102.87 kb | 352 |
| Super Monaco GP (USA) | 102.85 kb | 515 |
| Super Monaco GP (USA) (Beta 1) | 102.79 kb | 161 |
| Super Monaco GP (USA) (Beta 2) | 102.85 kb | 183 |
| Super Off Road (Europe) | 63.38 kb | 459 |
| Super Racing (Japan) | 109.28 kb | 515 |
| Super Smash T.V. (Europe) | 102.31 kb | 581 |
| Super Space Invaders (Europe) | 136.93 kb | 535 |
| Super Tennis (USA, Europe) | 22.34 kb | 544 |
| Super Tetris (Korea) (Pirate) | 22.80 kb | 338 |
| Super Wonder Boy - Monster World (Japan) | 130.88 kb | 818 |
| Super Wonder Boy (Japan, Europe) | 77.91 kb | 898 |
| Superman - The Man of Steel (Europe) | 87.92 kb | 676 |
