| Name | Size | DLs |
|---|
| Samurai Jack - The Shadow of Aku (USA) | 388.28 mb | 6887 |
| Scaler (USA) (En,Fr) | 548.21 mb | 8471 |
| Scooby-Doo! Mystery Mayhem (USA) | 717.35 mb | 6671 |
| Scooby-Doo! Night of 100 Frights (USA) | 678.19 mb | 3717 |
| Scooby-Doo! Night of 100 Frights (USA) (Rev 1) | 673.75 mb | 2480 |
| Scooby-Doo! Unmasked (USA) (En,Fr) | 299.82 mb | 4520 |
| Scorpion King, The - Rise of the Akkadian (USA) | 448.22 mb | 3148 |
| SeaWorld Adventure Parks - Shamus Deep Sea Adventures (USA) | 587.59 mb | 2771 |
| Second Sight (USA) | 740.27 mb | 5180 |
| Sega Soccer Slam (USA) | 373.65 mb | 4673 |
| Serious Sam - Next Encounter (USA) (Rev 1) | 904.70 mb | 4923 |
| Shadow The Hedgehog (USA) (En,Ja,Fr,De,Es,It) | 1.04 gb | 9809 |
| Shonen Jumps One Piece - Grand Adventure (USA) | 955.26 mb | 30093 |
| Shonen Jumps One Piece - Grand Battle (USA) | 716.50 mb | 24621 |
| Shonen Jumps One Piece - Pirates Carnival (USA) | 491.96 mb | 15168 |
| Shrek 2 (USA) | 923.68 mb | 6997 |
| Shrek Extra Large (USA) | 246.36 mb | 3654 |
| Shrek Super Party (USA) | 342.39 mb | 3536 |
| Simpsons, The - Hit & Run (USA) | 591.72 mb | 15037 |
| Simpsons, The - Road Rage (USA) | 447.63 mb | 7692 |
| Sims 2, The - Pets (USA) | 540.58 mb | 4557 |
| Sims 2, The (USA) | 735.46 mb | 5661 |
| Sims, The - Bustin Out (USA) | 961.75 mb | 5426 |
| Sims, The (USA) | 336.55 mb | 4171 |
| Skies of Arcadia Legends (USA) | 757.54 mb | 13011 |
| Smashing Drive (USA) | 77.48 mb | 2717 |
| Smugglers Run - Warzones (USA) | 1.19 gb | 5633 |
| Sonic Adventure 2 - Battle (USA) (En,Ja,Fr,De,Es) | 965.04 mb | 50162 |
| Sonic Adventure DX - Directors Cut (USA) (En,Ja,Fr,De,Es) | 965.59 mb | 32911 |
| Sonic Gems Collection (USA) | 1.01 gb | 13884 |
| Sonic Heroes (USA) (En,Ja,Fr,De,Es,It) | 888.99 mb | 48921 |
| Sonic Mega Collection (USA) | 785.05 mb | 10199 |
| Sonic Riders (USA) (En,Ja,Fr,De,Es,It) | 1.01 gb | 9315 |
| Soulcalibur II (USA) | 592.32 mb | 16736 |
| Soulcalibur II (USA) (Demo) | 75.24 mb | 1647 |
| Space Raiders (USA) | 515.13 mb | 3324 |
| Spartan - Total Warrior (USA) | 671.03 mb | 5095 |
| Spawn - Armageddon (USA) | 453.42 mb | 6080 |
| Speed Kings (USA) | 210.45 mb | 7632 |
| Sphinx and the Cursed Mummy (USA) | 463.22 mb | 5775 |
| Spider-Man (USA) | 614.01 mb | 7002 |
| Spider-Man 2 (USA) | 1.05 gb | 24236 |
| Spirits & Spells (USA) | 331.31 mb | 2554 |
| SpyHunter (USA) | 496.79 mb | 3817 |
| Spyro - A Heros Tail (USA) | 379.36 mb | 6803 |
| Spyro - Enter the Dragonfly (USA) | 210.19 mb | 7450 |
| SRS - Street Racing Syndicate (USA) | 861.05 mb | 4814 |
| SSX 3 (USA) | 829.69 mb | 7467 |
| SSX On Tour (USA) | 913.87 mb | 5502 |
| SSX Tricky (USA) | 727.99 mb | 6214 |
| Star Fox - Assault (USA) | 969.35 mb | 13436 |
| Star Fox Adventures (USA) | 412.31 mb | 8075 |
| Star Fox Adventures (USA) (Rev 1) | 412.38 mb | 14188 |
| Star Wars - Bounty Hunter (USA) | 1.11 gb | 9264 |
| Star Wars - Jedi Knight II - Jedi Outcast (USA) | 1.15 gb | 30676 |
| Star Wars - Rogue Squadron II - Rogue Leader (USA) | 1.26 gb | 30346 |
| Star Wars - Rogue Squadron III - Rebel Strike (USA) | 1.18 gb | 25495 |
| Star Wars - Rogue Squadron III - Rebel Strike (USA) (Limited Edition Preview Disc) | 594.52 mb | 2664 |
| Star Wars - The Clone Wars (USA) | 1.11 gb | 8869 |
| Starsky & Hutch (USA) | 514.72 mb | 2816 |
| Street Hoops (USA) | 991.74 mb | 3447 |
| Strike Force Bowling (USA) | 92.59 mb | 2204 |
| Sum of All Fears, The (USA) | 364.46 mb | 3133 |
| Summoner - A Goddess Reborn (USA) | 922.91 mb | 12234 |
| Super Bubble Pop (USA) | 183.13 mb | 7255 |
| Super Mario Strikers (USA) | 309.74 mb | 18881 |
| Super Mario Sunshine (USA) | 687.36 mb | 82073 |
| Super Monkey Ball (USA) | 229.17 mb | 13172 |
| Super Monkey Ball 2 (USA) | 499.20 mb | 19341 |
| Super Monkey Ball Adventure (USA) | 306.05 mb | 13087 |
| Super Smash Bros. Melee (USA) (En,Ja) | 958.57 mb | 27343 |
| Super Smash Bros. Melee (USA) (En,Ja) (Rev 1) | 958.55 mb | 5028 |
| Super Smash Bros. Melee (USA) (En,Ja) (Rev 2) | 958.45 mb | 16321 |
| Superman - Shadow of Apokolips (USA) | 1.09 gb | 598984 |
| Surfs Up (USA) (En,Fr,Es) | 1.21 gb | 3542 |
| Swingerz Golf (USA) | 780.05 mb | 10422 |
| SX Superstar (USA) | 405.27 mb | 2202 |
