| Name | Size | DLs |
|---|
| Samurai Jack - The Shadow of Aku (USA) | 458.56 mb | 174 |
| Scaler (USA) (En,Fr) | 892.33 mb | 79 |
| Scooby-Doo! Mystery Mayhem (USA) | 906.65 mb | 182 |
| Scooby-Doo! Night of 100 Frights (USA) (Rev 1) | 856.62 mb | 134 |
| Scooby-Doo! Unmasked (USA) (En,Fr) | 544.33 mb | 163 |
| Scorpion King, The - Rise of the Akkadian (USA) | 597.21 mb | 158 |
| SeaWorld Adventure Parks - Shamu's Deep Sea Adventures (USA) | 628.05 mb | 95 |
| Second Sight (USA) | 992.55 mb | 93 |
| Sega Soccer Slam (USA) | 435.51 mb | 140 |
| Serious Sam - Next Encounter (USA) (Rev 1) | 946.51 mb | 206 |
| Shonen Jump's One Piece - Grand Adventure (USA) | 1.04 gb | 123 |
| Shonen Jump's One Piece - Grand Battle (USA) | 806.70 mb | 95 |
| Shonen Jump's One Piece - Pirates' Carnival (USA) | 601.12 mb | 81 |
| Shrek 2 (USA) | 982.89 mb | 181 |
| Shrek Extra Large (USA) | 271.22 mb | 99 |
| Shrek Super Party (USA) | 506.11 mb | 92 |
| Simpsons, The - Hit & Run (USA) | 667.47 mb | 1150 |
| Simpsons, The - Road Rage (USA) | 581.99 mb | 326 |
| Sims 2, The - Pets (USA) | 651.21 mb | 168 |
| Sims 2, The (USA) | 849.30 mb | 207 |
| Sims, The - Bustin' Out (USA) | 1.09 gb | 113 |
| Sims, The (USA) | 360.66 mb | 107 |
| Skies of Arcadia Legends (USA) | 1.26 gb | 249 |
| Smashing Drive (USA) | 106.75 mb | 67 |
| Smuggler's Run - Warzones (USA) | 1.23 gb | 109 |
| Sonic Adventure 2 - Battle (USA) (En,Ja,Fr,De,Es) | 1.14 gb | 488 |
| Sonic Adventure DX - Director's Cut (USA) (En,Ja,Fr,De,Es) | 1.15 gb | 487 |
| Sonic Adventure DX (Japan) (En,Ja,Fr,De,Es) | 1.15 gb | 97 |
| Sonic Gems Collection (USA) | 1.16 gb | 373 |
| Sonic Heroes (USA) (En,Ja,Fr,De,Es,It) | 995.74 mb | 527 |
| Sonic Mega Collection (USA) | 827.08 mb | 450 |
| Sonic Riders (USA) (En,Ja,Fr,De,Es,It) | 1.22 gb | 326 |
| Soulcalibur II (USA) | 761.51 mb | 601 |
| Space Raiders (USA) | 558.86 mb | 76 |
| Spartan - Total Warrior (USA) | 974.25 mb | 150 |
| Spawn - Armageddon (USA) | 671.06 mb | 141 |
| Speed Challenge - Jacques Villeneuve's Racing Vision (Europe) (En,Fr) | 394.14 mb | 72 |
| Speed Kings (USA) | 256.35 mb | 64 |
| Sphinx and the Cursed Mummy (USA) | 598.03 mb | 95 |
| Spider-Man (USA) (Rev 1) | 896.17 mb | 216 |
| Spider-Man 2 (USA) | 1.16 gb | 306 |
| Spirits & Spells (USA) | 447.24 mb | 64 |
| SpyHunter (USA) | 636.30 mb | 99 |
| Spyro - A Hero's Tail (USA) | 477.50 mb | 189 |
| Spyro - Enter the Dragonfly (USA) | 361.40 mb | 150 |
| SRS - Street Racing Syndicate (USA) | 1.06 gb | 94 |
| SSX 3 (USA) | 1.02 gb | 278 |
| SSX On Tour (USA) | 1.01 gb | 108 |
| SSX Tricky (USA) | 795.43 mb | 195 |
| Star Fox - Assault (USA) | 1.08 gb | 279 |
| Star Fox Adventures (USA) (Rev 1) | 529.21 mb | 318 |
| Star Wars - Bounty Hunter (USA) | 1.22 gb | 148 |
| Star Wars - Jedi Knight II - Jedi Outcast (USA) | 1.17 gb | 189 |
| Star Wars - Rogue Squadron II - Rogue Leader (USA) | 1.30 gb | 393 |
| Star Wars - Rogue Squadron III - Rebel Strike (USA) | 1.30 gb | 348 |
| Star Wars - The Clone Wars (USA) | 1.17 gb | 154 |
| Starsky & Hutch (USA) | 777.56 mb | 89 |
| Street Hoops (USA) | 1.22 gb | 67 |
| Strike Force Bowling (USA) | 149.68 mb | 80 |
| Sum of All Fears, The (USA) | 455.71 mb | 59 |
| Summoner - A Goddess Reborn (USA) | 1.03 gb | 84 |
| Super Bubble Pop (USA) | 189.49 mb | 57 |
| Super Mario Strikers (USA) | 414.53 mb | 562 |
| Super Mario Sunshine (USA) | 985.54 mb | 1832 |
| Super Monkey Ball (USA) | 288.25 mb | 395 |
| Super Monkey Ball 2 (USA) | 633.61 mb | 338 |
| Super Monkey Ball Adventure (USA) | 447.10 mb | 127 |
| Super Puzzle Bobble All Stars (Korea) | 64.21 mb | 56 |
| Super Smash Bros. Melee (USA) (En,Ja) (Rev 2) | 1.09 gb | 1838 |
| Superman - Shadow of Apokolips (USA) | 1.17 gb | 204 |
| Surf's Up (USA) (En,Fr,Es) | 1.35 gb | 79 |
| Swingerz Golf (USA) | 1.06 gb | 89 |
| SX Superstar (USA) | 507.02 mb | 76 |
