| Name | Size | DLs |
|---|
| Samurai Shodown (Japan) (En,Ja) | 384.86 mb | 12922 |
| Samurai Shodown (USA, Europe) | 341.34 mb | 4101 |
| Sangokushi IV (Japan) | 215.41 mb | 2469 |
| Scramble Cobra (Europe) | 218.32 mb | 1181 |
| Scramble Cobra (Japan) | 218.31 mb | 894 |
| Scramble Cobra (Japan) (Demo) | 70.18 mb | 643 |
| Scramble Cobra (USA) | 217.24 mb | 1491 |
| Seal of the Pharaoh (USA) | 235.78 mb | 2054 |
| Secre Fuumin no Omochabako (Japan) | 371.80 mb | 1387 |
| Seimei Handan (Japan) | 113.54 mb | 1115 |
| Sento Monogatari - Sono I (Japan) | 457.38 mb | 1092 |
| Sesame Street - Numbers (Japan) | 295.39 mb | 1015 |
| Sesame Street - Numbers (USA) | 308.40 mb | 2337 |
| Sewer Shark (USA) | 532.95 mb | 2742 |
| Sex (USA) | 283.98 mb | 8167 |
| SHADOW - War of Succession (USA) | 152.08 mb | 2643 |
| SHADOW Warriors (Japan) | 148.75 mb | 1370 |
| Shanghai - Banri no Choujou - The Great Wall (Japan) (Rev 1) | 67.71 mb | 1085 |
| Shanghai - Triple-Threat (USA) | 67.60 mb | 1741 |
| Shanghai - Triple-Threat (USA) (3DO Action Pak) | 67.60 mb | 973 |
| Shelley Duvall's It's a Bird's Life (USA) | 119.36 mb | 1981 |
| Shock Wave - Operation JumpGate (Japan) | 127.69 mb | 812 |
| Shock Wave - Operation JumpGate (Japan) (Demo) | 48.28 mb | 603 |
| Shock Wave - Operation JumpGate (USA, Europe) | 129.69 mb | 2009 |
| Shock Wave (Europe) | 356.73 mb | 1618 |
| Shock Wave (Japan) | 353.38 mb | 785 |
| Shock Wave (Japan) (Demo) | 54.42 mb | 507 |
| Shock Wave (USA) (RE1) | 416.50 mb | 1584 |
| Shock Wave (USA) (RE2) | 356.73 mb | 1546 |
| Shockwave 2 - Beyond the Gate (Europe) (Disc 1) | 416.86 mb | 1066 |
| Shockwave 2 - Beyond the Gate (Europe) (Disc 2) | 420.12 mb | 1067 |
| Shockwave 2 - Beyond the Gate (USA) (Disc 01) | 416.86 mb | 2048 |
| Shockwave 2 - Beyond the Gate (USA) (Disc 02) | 420.11 mb | 1989 |
| Short Warp - Warp's Short Game Collection (Japan) | 163.28 mb | 1316 |
| Sid Meier's C.P.U. Bach (USA) | 121.24 mb | 1681 |
| Slam 'n Jam '95 (Japan) | 54.81 mb | 711 |
| Slam 'n Jam '95 (USA, Europe) | 54.78 mb | 1840 |
| Slayer (USA) | 204.99 mb | 2606 |
| Slayer (USA) (3DO Action Pak) | 204.99 mb | 891 |
| Slopestyle - An Interactive Learning Cube (USA) | 390.58 mb | 1496 |
| SnowJob (Europe) (Disc 1) | 331.16 mb | 1774 |
| SnowJob (Europe) (Disc 2) | 336.05 mb | 1785 |
| Soccer Kid (Europe) | 366.58 mb | 1173 |
| Soccer Kid (USA) | 352.76 mb | 2026 |
| Sotsugyou - Graduation - Final (Japan) | 466.48 mb | 1583 |
| Sotsugyou - Graduation - Final (Japan) (Demo) | 466.36 mb | 645 |
| Sotsugyou II Special - Neo Generation (Japan) | 228.74 mb | 1616 |
| Space Ace (Europe) (Demo) | 35.10 mb | 504 |
| Space Ace (USA) | 229.43 mb | 2843 |
| Space Hulk - Vengeance of the Blood Angels (Europe) | 189.80 mb | 1204 |
| Space Hulk - Vengeance of the Blood Angels (USA) | 189.80 mb | 2707 |
| Space Pirates (USA) | 368.42 mb | 2497 |
| Star Control II - The Ur-Quan Masters (Japan) | 389.93 mb | 1191 |
| Star Control II (USA) | 478.82 mb | 4225 |
| Star Fighter (Europe) (Demo) | 18.47 mb | 491 |
| Star Fighter (USA, Europe) | 295.50 mb | 3066 |
| Star Wars - Rebel Assault (Japan) | 219.92 mb | 1163 |
| Star Wars - Rebel Assault (USA, Europe) | 220.00 mb | 3287 |
| Starblade (Canada) | 299.14 mb | 1512 |
| Starblade (Europe, Germany) | 295.18 mb | 2466 |
| Starblade (Japan) | 299.14 mb | 1390 |
| Starblade (Japan) (Demo) | 107.38 mb | 532 |
| Stellar 7 - Draxon's Revenge (Japan) | 214.66 mb | 782 |
| Stellar 7 - Draxon's Revenge (USA) | 212.16 mb | 2283 |
| Step Aerobics (USA) | 459.27 mb | 1969 |
| Storage Manager - Memory Kanri (Japan) | 567.52 kb | 556 |
| Strahl (Japan) | 353.80 mb | 782 |
| Strahl (USA) | 411.15 mb | 2431 |
| Striker - World Cup Special (Europe) | 250.76 mb | 2397 |
| Super Real Mahjong P.V (Japan) | 287.34 mb | 2467 |
| Super Real Mahjong PIV + Aishou Shindan (Japan) | 63.57 mb | 1587 |
| Super Street Fighter II Turbo (Europe) | 201.46 mb | 1735 |
| Super Street Fighter II Turbo (Europe) (Demo) (3DO Magazine - Issue 10) | 88.95 mb | 640 |
| Super Street Fighter II Turbo (USA, Canada) (RE1) | 201.46 mb | 845 |
| Super Street Fighter II Turbo (USA) | 201.45 mb | 6742 |
| Super Street Fighter II Turbo (USA) (RE2) | 201.46 mb | 2023 |
| Super Street Fighter II X - Grand Master Challenge (Japan, Europe) (Demo) | 88.95 mb | 793 |
| Super Street Fighter II X - Grand Master Challenge (Japan) | 201.46 mb | 7162 |
| Super Wing Commander (Europe) | 363.60 mb | 1702 |
| Super Wing Commander (Japan) | 303.41 mb | 751 |
| Super Wing Commander (Korea) | 338.07 mb | 534 |
| Super Wing Commander (USA) | 338.07 mb | 2166 |
| SuperModels Go Wild (USA) | 474.85 mb | 401 |
| Supreme Warrior (Japan) (Ja,Zh) (Disc 1) (Fire & Earth) | 484.92 mb | 1706 |
| Supreme Warrior (Japan) (Ja,Zh) (Disc 2) (Wind & Fang Tu) | 438.35 mb | 1474 |
| Supreme Warrior (USA) (Disc 2) (Wind & Fang Tu) | 437.45 mb | 1346 |
| Sword & Sorcery (Japan) | 136.01 mb | 1221 |
| Sword & Sorcery (Japan) (Demo) | 58.48 mb | 637 |
| Syndicate (Europe) | 65.59 mb | 1762 |
| Syndicate (Europe) (Demo) | 65.54 mb | 583 |
| Syndicate (Japan) | 67.86 mb | 707 |
