| Name | Size | DLs |
|---|
| Samurai Shodown (Japan) (En,Ja) | 384.86 mb | 14155 |
| Samurai Shodown (USA, Europe) | 341.34 mb | 5865 |
| Sangokushi IV (Japan) | 215.41 mb | 3015 |
| Scramble Cobra (Europe) | 218.32 mb | 1514 |
| Scramble Cobra (Japan) | 218.31 mb | 1199 |
| Scramble Cobra (Japan) (Demo) | 70.18 mb | 786 |
| Scramble Cobra (USA) | 217.24 mb | 2182 |
| Seal of the Pharaoh (USA) | 235.78 mb | 2826 |
| Secre Fuumin no Omochabako (Japan) | 371.80 mb | 1936 |
| Seimei Handan (Japan) | 113.54 mb | 1472 |
| Sento Monogatari - Sono I (Japan) | 457.38 mb | 1429 |
| Sesame Street - Numbers (Japan) | 295.39 mb | 1208 |
| Sesame Street - Numbers (USA) | 308.40 mb | 2922 |
| Sewer Shark (USA) | 532.95 mb | 3798 |
| Sex (USA) | 283.98 mb | 11339 |
| SHADOW - War of Succession (USA) | 152.08 mb | 3502 |
| SHADOW Warriors (Japan) | 148.75 mb | 1884 |
| Shanghai - Banri no Choujou - The Great Wall (Japan) (Rev 1) | 67.71 mb | 1371 |
| Shanghai - Triple-Threat (USA) | 67.60 mb | 2297 |
| Shanghai - Triple-Threat (USA) (3DO Action Pak) | 67.60 mb | 1233 |
| Shelley Duvall's It's a Bird's Life (USA) | 119.36 mb | 2630 |
| Shock Wave - Operation JumpGate (Japan) | 127.69 mb | 1042 |
| Shock Wave - Operation JumpGate (Japan) (Demo) | 48.28 mb | 731 |
| Shock Wave - Operation JumpGate (USA, Europe) | 129.69 mb | 2775 |
| Shock Wave (Europe) | 356.73 mb | 1961 |
| Shock Wave (Japan) | 353.38 mb | 1041 |
| Shock Wave (Japan) (Demo) | 54.42 mb | 647 |
| Shock Wave (USA) (RE1) | 416.50 mb | 1933 |
| Shock Wave (USA) (RE2) | 356.73 mb | 2232 |
| Shockwave 2 - Beyond the Gate (Europe) (Disc 1) | 416.86 mb | 1377 |
| Shockwave 2 - Beyond the Gate (Europe) (Disc 2) | 420.12 mb | 1354 |
| Shockwave 2 - Beyond the Gate (USA) (Disc 01) | 416.86 mb | 2811 |
| Shockwave 2 - Beyond the Gate (USA) (Disc 02) | 420.11 mb | 2739 |
| Short Warp - Warp's Short Game Collection (Japan) | 163.28 mb | 1737 |
| Sid Meier's C.P.U. Bach (USA) | 121.24 mb | 2459 |
| Slam 'n Jam '95 (Japan) | 54.81 mb | 927 |
| Slam 'n Jam '95 (USA, Europe) | 54.78 mb | 2687 |
| Slayer (USA) | 204.99 mb | 3601 |
| Slayer (USA) (3DO Action Pak) | 204.99 mb | 1217 |
| Slopestyle - An Interactive Learning Cube (USA) | 390.58 mb | 2001 |
| SnowJob (Europe) (Disc 1) | 331.16 mb | 2503 |
| SnowJob (Europe) (Disc 2) | 336.05 mb | 2504 |
| Soccer Kid (Europe) | 366.58 mb | 1572 |
| Soccer Kid (USA) | 352.76 mb | 2767 |
| Sotsugyou - Graduation - Final (Japan) | 466.48 mb | 2063 |
| Sotsugyou - Graduation - Final (Japan) (Demo) | 466.36 mb | 805 |
| Sotsugyou II Special - Neo Generation (Japan) | 228.74 mb | 2045 |
| Space Ace (Europe) (Demo) | 35.10 mb | 630 |
| Space Ace (USA) | 229.43 mb | 3900 |
| Space Hulk - Vengeance of the Blood Angels (Europe) | 189.80 mb | 1578 |
| Space Hulk - Vengeance of the Blood Angels (USA) | 189.80 mb | 3662 |
| Space Pirates (USA) | 368.42 mb | 3403 |
| Star Control II - The Ur-Quan Masters (Japan) | 389.93 mb | 1481 |
| Star Control II (USA) | 478.82 mb | 5440 |
| Star Fighter (Europe) (Demo) | 18.47 mb | 641 |
| Star Fighter (USA, Europe) | 295.50 mb | 4158 |
| Star Wars - Rebel Assault (Japan) | 219.92 mb | 1436 |
| Star Wars - Rebel Assault (USA, Europe) | 220.00 mb | 4518 |
| Starblade (Canada) | 299.14 mb | 2003 |
| Starblade (Europe, Germany) | 295.18 mb | 2956 |
| Starblade (Japan) | 299.14 mb | 1734 |
| Starblade (Japan) (Demo) | 107.38 mb | 679 |
| Stellar 7 - Draxon's Revenge (Japan) | 214.66 mb | 1009 |
| Stellar 7 - Draxon's Revenge (USA) | 212.16 mb | 2995 |
| Step Aerobics (USA) | 459.27 mb | 2543 |
| Storage Manager - Memory Kanri (Japan) | 567.52 kb | 790 |
| Strahl (Japan) | 353.80 mb | 1078 |
| Strahl (USA) | 411.15 mb | 3272 |
| Striker - World Cup Special (Europe) | 250.76 mb | 2974 |
| Super Real Mahjong P.V (Japan) | 287.34 mb | 3009 |
| Super Real Mahjong PIV + Aishou Shindan (Japan) | 63.57 mb | 1993 |
| Super Street Fighter II Turbo (Europe) | 201.46 mb | 2235 |
| Super Street Fighter II Turbo (Europe) (Demo) (3DO Magazine - Issue 10) | 88.95 mb | 775 |
| Super Street Fighter II Turbo (USA, Canada) (RE1) | 201.46 mb | 1231 |
| Super Street Fighter II Turbo (USA) | 201.45 mb | 7915 |
| Super Street Fighter II Turbo (USA) (RE2) | 201.46 mb | 3120 |
| Super Street Fighter II X - Grand Master Challenge (Japan, Europe) (Demo) | 88.95 mb | 995 |
| Super Street Fighter II X - Grand Master Challenge (Japan) | 201.46 mb | 8359 |
| Super Wing Commander (Europe) | 363.60 mb | 2114 |
| Super Wing Commander (Japan) | 303.41 mb | 1049 |
| Super Wing Commander (Korea) | 338.07 mb | 675 |
| Super Wing Commander (USA) | 338.07 mb | 3105 |
| SuperModels Go Wild (USA) | 474.85 mb | 1982 |
| Supreme Warrior (Japan) (Ja,Zh) (Disc 1) (Fire & Earth) | 484.92 mb | 2236 |
| Supreme Warrior (Japan) (Ja,Zh) (Disc 2) (Wind & Fang Tu) | 438.35 mb | 1921 |
| Supreme Warrior (USA) (Disc 2) (Wind & Fang Tu) | 437.45 mb | 1735 |
| Sword & Sorcery (Japan) | 136.01 mb | 1685 |
| Sword & Sorcery (Japan) (Demo) | 58.48 mb | 764 |
| Syndicate (Europe) | 65.59 mb | 2448 |
| Syndicate (Europe) (Demo) | 65.54 mb | 710 |
| Syndicate (Japan) | 67.86 mb | 964 |
