| Name | Size | DLs |
|---|
| Samurai Shodown (Japan) (En,Ja) | 384.86 mb | 14555 |
| Samurai Shodown (USA, Europe) | 341.34 mb | 6373 |
| Sangokushi IV (Japan) | 215.41 mb | 3186 |
| Scramble Cobra (Europe) | 218.32 mb | 1687 |
| Scramble Cobra (Japan) | 218.31 mb | 1315 |
| Scramble Cobra (Japan) (Demo) | 70.18 mb | 886 |
| Scramble Cobra (USA) | 217.24 mb | 2428 |
| Seal of the Pharaoh (USA) | 235.78 mb | 3107 |
| Secre Fuumin no Omochabako (Japan) | 371.80 mb | 2113 |
| Seimei Handan (Japan) | 113.54 mb | 1647 |
| Sento Monogatari - Sono I (Japan) | 457.38 mb | 1595 |
| Sesame Street - Numbers (Japan) | 295.39 mb | 1309 |
| Sesame Street - Numbers (USA) | 308.40 mb | 3163 |
| Sewer Shark (USA) | 532.95 mb | 4220 |
| Sex (USA) | 283.98 mb | 12937 |
| SHADOW - War of Succession (USA) | 152.08 mb | 3806 |
| SHADOW Warriors (Japan) | 148.75 mb | 2045 |
| Shanghai - Banri no Choujou - The Great Wall (Japan) (Rev 1) | 67.71 mb | 1530 |
| Shanghai - Triple-Threat (USA) | 67.60 mb | 2506 |
| Shanghai - Triple-Threat (USA) (3DO Action Pak) | 67.60 mb | 1354 |
| Shelley Duvall's It's a Bird's Life (USA) | 119.36 mb | 2841 |
| Shock Wave - Operation JumpGate (Japan) | 127.69 mb | 1187 |
| Shock Wave - Operation JumpGate (Japan) (Demo) | 48.28 mb | 826 |
| Shock Wave - Operation JumpGate (USA, Europe) | 129.69 mb | 3043 |
| Shock Wave (Europe) | 356.73 mb | 2112 |
| Shock Wave (Japan) | 353.38 mb | 1202 |
| Shock Wave (Japan) (Demo) | 54.42 mb | 728 |
| Shock Wave (USA) (RE1) | 416.50 mb | 2097 |
| Shock Wave (USA) (RE2) | 356.73 mb | 2446 |
| Shockwave 2 - Beyond the Gate (Europe) (Disc 1) | 416.86 mb | 1547 |
| Shockwave 2 - Beyond the Gate (Europe) (Disc 2) | 420.12 mb | 1491 |
| Shockwave 2 - Beyond the Gate (USA) (Disc 01) | 416.86 mb | 3040 |
| Shockwave 2 - Beyond the Gate (USA) (Disc 02) | 420.11 mb | 2980 |
| Short Warp - Warp's Short Game Collection (Japan) | 163.28 mb | 1923 |
| Sid Meier's C.P.U. Bach (USA) | 121.24 mb | 2714 |
| Slam 'n Jam '95 (Japan) | 54.81 mb | 1067 |
| Slam 'n Jam '95 (USA, Europe) | 54.78 mb | 2986 |
| Slayer (USA) | 204.99 mb | 3969 |
| Slayer (USA) (3DO Action Pak) | 204.99 mb | 1379 |
| Slopestyle - An Interactive Learning Cube (USA) | 390.58 mb | 2202 |
| SnowJob (Europe) (Disc 1) | 331.16 mb | 2721 |
| SnowJob (Europe) (Disc 2) | 336.05 mb | 2706 |
| Soccer Kid (Europe) | 366.58 mb | 1769 |
| Soccer Kid (USA) | 352.76 mb | 3027 |
| Sotsugyou - Graduation - Final (Japan) | 466.48 mb | 2259 |
| Sotsugyou - Graduation - Final (Japan) (Demo) | 466.36 mb | 920 |
| Sotsugyou II Special - Neo Generation (Japan) | 228.74 mb | 2209 |
| Space Ace (Europe) (Demo) | 35.10 mb | 751 |
| Space Ace (USA) | 229.43 mb | 4229 |
| Space Hulk - Vengeance of the Blood Angels (Europe) | 189.80 mb | 1781 |
| Space Hulk - Vengeance of the Blood Angels (USA) | 189.80 mb | 4023 |
| Space Pirates (USA) | 368.42 mb | 3729 |
| Star Control II - The Ur-Quan Masters (Japan) | 389.93 mb | 1636 |
| Star Control II (USA) | 478.82 mb | 6028 |
| Star Fighter (Europe) (Demo) | 18.47 mb | 755 |
| Star Fighter (USA, Europe) | 295.50 mb | 4561 |
| Star Wars - Rebel Assault (Japan) | 219.92 mb | 1573 |
| Star Wars - Rebel Assault (USA, Europe) | 220.00 mb | 4879 |
| Starblade (Canada) | 299.14 mb | 2213 |
| Starblade (Europe, Germany) | 295.18 mb | 3147 |
| Starblade (Japan) | 299.14 mb | 1898 |
| Starblade (Japan) (Demo) | 107.38 mb | 762 |
| Stellar 7 - Draxon's Revenge (Japan) | 214.66 mb | 1128 |
| Stellar 7 - Draxon's Revenge (USA) | 212.16 mb | 3313 |
| Step Aerobics (USA) | 459.27 mb | 2742 |
| Storage Manager - Memory Kanri (Japan) | 567.52 kb | 909 |
| Strahl (Japan) | 353.80 mb | 1208 |
| Strahl (USA) | 411.15 mb | 3642 |
| Striker - World Cup Special (Europe) | 250.76 mb | 3174 |
| Super Real Mahjong P.V (Japan) | 287.34 mb | 3248 |
| Super Real Mahjong PIV + Aishou Shindan (Japan) | 63.57 mb | 2193 |
| Super Street Fighter II Turbo (Europe) | 201.46 mb | 2467 |
| Super Street Fighter II Turbo (Europe) (Demo) (3DO Magazine - Issue 10) | 88.95 mb | 863 |
| Super Street Fighter II Turbo (USA, Canada) (RE1) | 201.46 mb | 1407 |
| Super Street Fighter II Turbo (USA) | 201.45 mb | 8324 |
| Super Street Fighter II Turbo (USA) (RE2) | 201.46 mb | 3395 |
| Super Street Fighter II X - Grand Master Challenge (Japan, Europe) (Demo) | 88.95 mb | 1119 |
| Super Street Fighter II X - Grand Master Challenge (Japan) | 201.46 mb | 8866 |
| Super Wing Commander (Europe) | 363.60 mb | 2324 |
| Super Wing Commander (Japan) | 303.41 mb | 1178 |
| Super Wing Commander (Korea) | 338.07 mb | 799 |
| Super Wing Commander (USA) | 338.07 mb | 3410 |
| SuperModels Go Wild (USA) | 474.85 mb | 2321 |
| Supreme Warrior (Japan) (Ja,Zh) (Disc 1) (Fire & Earth) | 484.92 mb | 2411 |
| Supreme Warrior (Japan) (Ja,Zh) (Disc 2) (Wind & Fang Tu) | 438.35 mb | 2063 |
| Supreme Warrior (USA) (Disc 2) (Wind & Fang Tu) | 437.45 mb | 1913 |
| Sword & Sorcery (Japan) | 136.01 mb | 1855 |
| Sword & Sorcery (Japan) (Demo) | 58.48 mb | 865 |
| Syndicate (Europe) | 65.59 mb | 2729 |
| Syndicate (Europe) (Demo) | 65.54 mb | 802 |
| Syndicate (Japan) | 67.86 mb | 1094 |
