| Name | Size | DLs |
|---|
| Samurai Shodown (Japan) (En,Ja) | 384.86 mb | 14030 |
| Samurai Shodown (USA, Europe) | 341.34 mb | 5595 |
| Sangokushi IV (Japan) | 215.41 mb | 2930 |
| Scramble Cobra (Europe) | 218.32 mb | 1427 |
| Scramble Cobra (Japan) | 218.31 mb | 1112 |
| Scramble Cobra (Japan) (Demo) | 70.18 mb | 744 |
| Scramble Cobra (USA) | 217.24 mb | 2046 |
| Seal of the Pharaoh (USA) | 235.78 mb | 2704 |
| Secre Fuumin no Omochabako (Japan) | 371.80 mb | 1830 |
| Seimei Handan (Japan) | 113.54 mb | 1419 |
| Sento Monogatari - Sono I (Japan) | 457.38 mb | 1351 |
| Sesame Street - Numbers (Japan) | 295.39 mb | 1154 |
| Sesame Street - Numbers (USA) | 308.40 mb | 2822 |
| Sewer Shark (USA) | 532.95 mb | 3621 |
| Sex (USA) | 283.98 mb | 10799 |
| SHADOW - War of Succession (USA) | 152.08 mb | 3359 |
| SHADOW Warriors (Japan) | 148.75 mb | 1798 |
| Shanghai - Banri no Choujou - The Great Wall (Japan) (Rev 1) | 67.71 mb | 1283 |
| Shanghai - Triple-Threat (USA) | 67.60 mb | 2204 |
| Shanghai - Triple-Threat (USA) (3DO Action Pak) | 67.60 mb | 1182 |
| Shelley Duvall's It's a Bird's Life (USA) | 119.36 mb | 2475 |
| Shock Wave - Operation JumpGate (Japan) | 127.69 mb | 954 |
| Shock Wave - Operation JumpGate (Japan) (Demo) | 48.28 mb | 691 |
| Shock Wave - Operation JumpGate (USA, Europe) | 129.69 mb | 2648 |
| Shock Wave (Europe) | 356.73 mb | 1876 |
| Shock Wave (Japan) | 353.38 mb | 942 |
| Shock Wave (Japan) (Demo) | 54.42 mb | 600 |
| Shock Wave (USA) (RE1) | 416.50 mb | 1860 |
| Shock Wave (USA) (RE2) | 356.73 mb | 2117 |
| Shockwave 2 - Beyond the Gate (Europe) (Disc 1) | 416.86 mb | 1303 |
| Shockwave 2 - Beyond the Gate (Europe) (Disc 2) | 420.12 mb | 1291 |
| Shockwave 2 - Beyond the Gate (USA) (Disc 01) | 416.86 mb | 2692 |
| Shockwave 2 - Beyond the Gate (USA) (Disc 02) | 420.11 mb | 2617 |
| Short Warp - Warp's Short Game Collection (Japan) | 163.28 mb | 1643 |
| Sid Meier's C.P.U. Bach (USA) | 121.24 mb | 2321 |
| Slam 'n Jam '95 (Japan) | 54.81 mb | 857 |
| Slam 'n Jam '95 (USA, Europe) | 54.78 mb | 2569 |
| Slayer (USA) | 204.99 mb | 3386 |
| Slayer (USA) (3DO Action Pak) | 204.99 mb | 1150 |
| Slopestyle - An Interactive Learning Cube (USA) | 390.58 mb | 1913 |
| SnowJob (Europe) (Disc 1) | 331.16 mb | 2386 |
| SnowJob (Europe) (Disc 2) | 336.05 mb | 2397 |
| Soccer Kid (Europe) | 366.58 mb | 1515 |
| Soccer Kid (USA) | 352.76 mb | 2625 |
| Sotsugyou - Graduation - Final (Japan) | 466.48 mb | 1963 |
| Sotsugyou - Graduation - Final (Japan) (Demo) | 466.36 mb | 735 |
| Sotsugyou II Special - Neo Generation (Japan) | 228.74 mb | 1975 |
| Space Ace (Europe) (Demo) | 35.10 mb | 604 |
| Space Ace (USA) | 229.43 mb | 3708 |
| Space Hulk - Vengeance of the Blood Angels (Europe) | 189.80 mb | 1505 |
| Space Hulk - Vengeance of the Blood Angels (USA) | 189.80 mb | 3461 |
| Space Pirates (USA) | 368.42 mb | 3264 |
| Star Control II - The Ur-Quan Masters (Japan) | 389.93 mb | 1376 |
| Star Control II (USA) | 478.82 mb | 5236 |
| Star Fighter (Europe) (Demo) | 18.47 mb | 593 |
| Star Fighter (USA, Europe) | 295.50 mb | 3946 |
| Star Wars - Rebel Assault (Japan) | 219.92 mb | 1338 |
| Star Wars - Rebel Assault (USA, Europe) | 220.00 mb | 4338 |
| Starblade (Canada) | 299.14 mb | 1895 |
| Starblade (Europe, Germany) | 295.18 mb | 2868 |
| Starblade (Japan) | 299.14 mb | 1663 |
| Starblade (Japan) (Demo) | 107.38 mb | 618 |
| Stellar 7 - Draxon's Revenge (Japan) | 214.66 mb | 929 |
| Stellar 7 - Draxon's Revenge (USA) | 212.16 mb | 2876 |
| Step Aerobics (USA) | 459.27 mb | 2454 |
| Storage Manager - Memory Kanri (Japan) | 567.52 kb | 743 |
| Strahl (Japan) | 353.80 mb | 976 |
| Strahl (USA) | 411.15 mb | 3107 |
| Striker - World Cup Special (Europe) | 250.76 mb | 2866 |
| Super Real Mahjong P.V (Japan) | 287.34 mb | 2885 |
| Super Real Mahjong PIV + Aishou Shindan (Japan) | 63.57 mb | 1914 |
| Super Street Fighter II Turbo (Europe) | 201.46 mb | 2143 |
| Super Street Fighter II Turbo (Europe) (Demo) (3DO Magazine - Issue 10) | 88.95 mb | 741 |
| Super Street Fighter II Turbo (USA, Canada) (RE1) | 201.46 mb | 1180 |
| Super Street Fighter II Turbo (USA) | 201.45 mb | 7710 |
| Super Street Fighter II Turbo (USA) (RE2) | 201.46 mb | 2981 |
| Super Street Fighter II X - Grand Master Challenge (Japan, Europe) (Demo) | 88.95 mb | 941 |
| Super Street Fighter II X - Grand Master Challenge (Japan) | 201.46 mb | 8127 |
| Super Wing Commander (Europe) | 363.60 mb | 2016 |
| Super Wing Commander (Japan) | 303.41 mb | 946 |
| Super Wing Commander (Korea) | 338.07 mb | 621 |
| Super Wing Commander (USA) | 338.07 mb | 2893 |
| SuperModels Go Wild (USA) | 474.85 mb | 1821 |
| Supreme Warrior (Japan) (Ja,Zh) (Disc 1) (Fire & Earth) | 484.92 mb | 2151 |
| Supreme Warrior (Japan) (Ja,Zh) (Disc 2) (Wind & Fang Tu) | 438.35 mb | 1853 |
| Supreme Warrior (USA) (Disc 2) (Wind & Fang Tu) | 437.45 mb | 1686 |
| Sword & Sorcery (Japan) | 136.01 mb | 1602 |
| Sword & Sorcery (Japan) (Demo) | 58.48 mb | 730 |
| Syndicate (Europe) | 65.59 mb | 2313 |
| Syndicate (Europe) (Demo) | 65.54 mb | 661 |
| Syndicate (Japan) | 67.86 mb | 888 |
